Physical Studies Institute (PSI) was a 501(c)(3) nonprofit scientific and educational California corporation I founded in 1970 and kept in operation through 1991. From 1980-1986, PSI was an independent agency account of the Institute for Pure and Applied Physical Sciences (IPAPS) at UC San Diego.

From 1970-1978 I personally funded and administrated the Institute for Study of Attention (ISA) High School, a subsidiary of PSI, developing and publishing an educational methodology emphasizing restructuring of standard text material to enhance personal learning strengths. We offered over 30 courses in academics, fine arts and physical disciplines.

From 1981-1986 I helped administrate another subsidiary, Conservatory of Ballet Arts Company (CBAC), consisting of over 100 students, and an active dancing group of about 30. CBAC was founded by my wife, Louise Ingber, an accomplished Ballet dancer. She has since founded Creek House Chocolates (see CreekHouseChocolates.com/about ).

In December 2019, I created the Sole Proprietorship "Physical Studies Institute" In February 2020, I created the Oregon LLC "Physical Studies Institute LLC" CEO Lester Ingber; at the same time I also created a DBA/ABN "Physical Studies Institute" to this LLC, permitting use of this name without the "LLC"

Catgories of projects are

From Feb 2013, as Principal Investigator (PI) of several National Science Foundation (NSF.gov) Extreme Science and Engineering Discovery Environment (XSEDE) supercomputer-resource grants, I have developed projects published in several papers. For more information about XSEDE see https://www.xsede.org .

The grants used these resources for applications of computational physics, based on some projects related to those I have worked on previously.

Work performed under a project, "Electroencephalographic field influence on calcium momentum waves" utilized an initial grant spanning 20 Feb 2013 - 19 Aug 2014 passed peer review for a second research grant spanning 1 Jul 2014 - 30 Jun 2015. On 20 Nov 2014 a request to double the current resources passed another round of review and was granted. In Jun 2015 another Renewal Request passed peer review, extending this grant through Jun 2016. On 15 Jun 2020 I was awarded another yearly grant starting 1 Jul 2020 through 30 Jun 2021.

The grant, "Quantum path-integral qPATHTREE and qPATHINT algorithms" through 30 Jun 2017 (extended through Dec 2017) shifted focus from computational neuroscience to broader contexts across computational physics, e.g., quantum financial options (more info below).

The paper below, https://www.ingber.com/path17_qpathint.pdf , was the core of a successful renewal grant for Jan-Dec 2018.

The current XSEDE grant from 6 Feb 2020, is to expand my SMNI model to include affective states, \*QAffective Modulation of Information Processing During Attention Tasks\*U, testing this with fits to new SEED data. SMNI models will be used to (a) first fit the P300 attentional data from alpha frequency bands to parameterized SMNI models, and (b) then use the affective part of the data primarily in beta and gamma frequency bands to fit the affective overlay described by its parameterized SMNI probability distribution. This project is as much about demonstrating a probabilistic model of human information processing that can be audited with respect to neocortical mechanisms, as it is about demonstrating the existence of EEG correlates to attention and affective behaviors.

However, at at first, the focus will be on establishing tight correlations between Affective states ad EEG data. There are a couple of good reasons for doing this:

Filtering into bands can open a Pandora's box of different filters. Using the raw data not only avoids this, but is a more robust method of fitting classificatios of data per brain/mind state.

The path to using all raw data, and considering the neurons per se, via SMNI, as the processors of patterns of information, is quite straightforward within the context of previous projects.

Data has been split and labelled, parsed down to Affective states.

- N = subject Number (1-15)
- S = Session (1-3)
- C = Columns of time {8601-51801}
- R = Run number (1-24)
- A = Affective state (0-3)
- Sample file (62 rows)
- f.N-5.S-1.C-43401.R-13.A-1
- and its transpose (62 columns)
- t.N-5.S-1.C-43401.R-13.A-1

Transpose matrices are available, e.g., to pull off time-domain lines per electrode.

"Mechanisms" will be connectivities across electrode-defined sites of neural activity.

This project calculates synchronous quantum systems and macroscopic systems with well-defined interactions.

This project was mapped out in several publications, recently in L. Ingber, ``Quantum calcium-ion interactions with EEG,'' Sci 1 (7), 1-21 (2018). [ URL https://www.ingber.com/smni18_quantumCaEEG.pdf and https://doi.org/10.3390/sci1010020 ] . The Abstract is given below, and that Conclusion is the starting point of this project.

This project would use quantum computing in one or both contexts:

(a) to perform the optimization of the cost/objective function over the space
of parameters defined by the SMNI model with EEG data as input.

(b) to propagate the Ca2+ wave function between EEG epochs in lock-step with
the changing magnetic vector potential defined by highly synchronous neuronal
firings.

Previous papers have developed a statistical mechanics of neocortical interactions (SMNI) fit to short-term memory and EEG data. Adaptive Simulated Annealing (ASA) has been developed to perform fits to such nonlinear stochastic systems. An N-dimensional path-integral algorithm for quantum systems, qPATHINT, has been developed from classical PATHINT. Both fold short-time propagators (distributions or wave functions) over long times. Previous papers applied qPATHINT to two systems, in neocortical interactions and financial options.

In this paper the quantum path-integral for Calcium ions is used to derive a closed-form analytic solution at arbitrary time that is used to calculate interactions with classical-physics SMNI interactions among scales. Using fits of this SMNI model to EEG data, including these effects, will help determine if this is a reasonable approach.

Methods of mathematical-physics for optimization and for path integrals in classical and quantum spaces are used for this project. Studies using supercomputer resources tested various dimensions for their scaling limits. In this paper the quantum path-integral is used to derive a closed-form analytic solution at arbitrary time that is used to calculate interactions with classical-physics SMNI interactions among scales.

The mathematical-physics and computer parts of the study are successful, in that there is modest improvement of cost/objective functions used to fit EEG data using these models.

This project points to directions for more detailed calculations using more EEG data and qPATHINT at each time slice to propagate quantum calcium waves, synchronized with PATHINT propagation of classical SMNI.

Thanks.

Lester Ingber

[email protected]

The 2016-2017 grant developed complex-number versions of PATHTREE and
PATHINT:

L. Ingber, C. Chen, R.P. Mondescu, D. Muzzall, and M. Renedo, "Probability tree
algorithm for general diffusion processes," Physical Review E 64 (5),
056702-056707 (2001). https://www.ingber.com/path01_pathtree.pdf

L. Ingber, "High-resolution path-integral development of financial options,"
Physica A 283 (3-4), 529-558 (2000). https://www.ingber.com/markets00_highres.pdf

Several other papers in my archive have used these codes.

A paper has shown the strengths and weaknesses of qPATHTREE and qPATHINT:

L. Ingber, "Path-integral quantum PATHTREE and PATHINT algorithms,"
International Journal of Innovative Research in Information Security 3 (5),
1-15 (2016). https://www.ingber.com/path16_quantum_path.pdf

Since this 2016 paper, qPATHINT has been properly baselined to PATHINT using
the same input and stochastic models, and applied to neuroscience and finance
problems:

L. Ingber, "Evolution of regenerative Ca-ion wave-packet in neuronal-firing
fields: Quantum path-integral with serial shocks," International Journal of
Innovative Research in Information Security 4 (2), 14-22 (2017). [ URL https://www.ingber.com/path17_quantum_pathint_shocks.pdf
]

L. Ingber, ``Options on quantum money: Quantum path-integral with serial
shocks,'' International Journal of Innovative Research in Information Security
4 (2), 7-13 (2017). [ URL https://www.ingber.com/path17_quantum_options_shocks.pdf
]

L. Ingber, "Quantum Path-Integral qPATHINT Algorithm," The Open Cybernetics
Systemics Journal 11, 3-18 (2017). [ URL https://www.ingber.com/path17_qpathint.pdf
]

qPATHTREE and qPATHTREE will provide researchers in several disciplines, in contexts utilizing path-integrals in many applied physics contexts, including problems in physics, neuroscience and blockchain derivatives, with a new fast numerical C-coded algorithm to perform path integrals of complex-number systems using the standard GCC compiler.

PATHTREE and PATHINT already have provided such algorithms for real-number
systems in several projects detailed at

https://www.ingber.com/#PATH-INTEGRAL
.

PATHINT and PATHTREE have been used to develop systems in neuroscience,
financial markets and combat analysis, as reported in several papers at

https://www.ingber.com/#NEOCORTEX

https://www.ingber.com/#MARKETS

https://www.ingber.com/#COMBAT
.

These papers deal with discretization issues that have been addressed in
several contexts, including theoretical physics as reported in several papers
at

https://www.ingber.com/#NUCLEAR
.

A related sub-project is to implement the N-dimensional code in PATHINT into PATHTREE.

See Lecture Plates: Quantum Variables in Finance and Neuroscience

https://l.ingber.com/lect2108

Lester

[To-Top-of-Archive] Lester Ingber <[email protected]> Copyright © 2013-2020 Lester Ingber. All Rights Reserved.

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